Research in Vestibular Science

Young Hyun Kim

5 Articles

Downbeat, Gaze-evoked and Perverted Head-shaking Nystagmus Associated with Dapsone Toxicity: Tae Woo Kim, Sun Young Oh, Ha Cheol Choi, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim; Res Vestib Sci. 2009;8(2):161-163.

Abstract PDF: Dapsone is an agent commonly used to treat leprosy and its most common adverse effect is a hemolytic anemia. We present a patient who showed transient downbeat, bilateral horizontal gaze-evoked nystagmus (GEN), and perverted head-shaking nystagmus after taking a large dose of dapsone. These oculomotor abnormalities are assumed to be a reversible vestibulocerebellar dysfunction caused by over-dose of dapsone.

Metronidazole-induced Reversible Cerebellopathy: Ha Cheol Choi, Sun Young Oh, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim; Res Vestib Sci. 2009;8(2):132-136.

Abstract PDF: Metronidazole is a nitroimidazole antibiotic used for anaerobic infections, protozoan infections, and Helicobacter pylori infections. It may produce rare but well known neurological adverse effects including peripheral neuropathy, encephalopathy, cerebellar dysfunction, and seizures. We describe three patients with metronidazole-induced reversible cerebellar dysfunctions characterized by abnormal oculomotor findings, dysmetria, and ataxia. The diagnosis of metronidazole toxicity was made clinically and supported by the brain MRI findings. The neurological signs and abnormal signal intensity on MRI resolved after discontinuation of metronidazole.

Two Cases of Methyl Bromide Intoxication Mimicking Bickerstaff’s Brainstem Encephalitis: Jin Young Seo, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim, Sun Young Oh; J Korean Bal Soc. 2008;7(2):199-203.

Abstract PDF: Background: Methyl bromide is toxic to the central and peripheral nervous systems. Two patients with occupational exposure to this agent are described. Case: Two cases of previously healthy young men were involved. They had worked in a fumigating plant spraying fruits using methyl bromide for several months before admission. They showed general weakness, severe ataxia, bilateral dysmetria and bilateral lateral gaze limitation. And gaze-evoked nystagmus was observed in one of them. Brain MRI showed symmetrically increased signal intensity lesions including the brainstem, cerebellum and splenium of corpus callosum. After conservative treatment, they gradually improved over the next few weeks. Conclusions: Symmetry and topography of our patients’ clinical and radiographic abnormalities support the proposal that methyl bromide exposure can produce symptoms similar to Bickerstaff’s brainstem encephalitis. Key words: Methyl bromide, Acute intoxication, Bickerstaff’s brainstem encephalitis

Two Cases of Congenital Ocular Motor Apraxia Associated With Cerebellar Vermian Dysplasia: Jin Young Seo, Yeon Hee Lee, Byoung Soo Shin, Man Wook Seo, Young Hyun Kim, Sun Young Oh; J Korean Bal Soc. 2008;7(1):63-67.

Abstract PDF: Congenital ocular motor apraxia is a rare syndrome characterized by rotational head thrusts that attempt to compensate for the lack of voluntary eye movements. We describe the clinical, oculographic and magnetic resonance imaging features of two children with congenital ocular motor apraxia.

Third Nerve Palsy in Idiopathic Hypereosinophilic Syndrome: Report of Two Cases: Mi Hye Lim, Byoung Soo Shin, Young Hyun Kim, Sun Young Oh; J Korean Bal Soc. 2007;6(2):234-238.

Abstract PDF: The idiopathic hypereosinophilic syndrome (IHES) is a heterogenous spectrum of disorders, characterized by a long lasting hypereosinophilia without identifiable underlying cause and by the presence of various end-organ dysfunction. The neurologic manifestations of IHES can be encephalopathy, organic psycho syndrome and polyneuropathy and in rare cases polymyositis. Central nervous system involvement is the second mostclinically important complication of the hypereosinophilic syndrome as it is associated with chronic disability and a poor prognosis. In this report, we describe two patients of IHES who presented anisolated third nerve palsy with pupillary involvement and were improved by corticosteroid therapy. They satisfied the criteria of IHES and the third cranial nerve was the only site of neurologic involvement. Early recognition of neurologic involvement in IHES and prompt treatment could lead to good outcome.

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